Fluid Retention & Swollen Legs Test
25 Biomarkers | Blood & Random Urine Sample | CE-marked | UKAS-accredited | Doctor-reviewed results with personalised interpretation.
A combined blood and urine test checking markers linked to swollen legs, fluid retention, kidney function, liver function, inflammation and urine health. Designed for people investigating puffiness, swelling or fluid-related symptoms, this profile gives clear, clinically reviewed insight into kidney, liver, inflammation and urine markers so you can better understand your results and know what to do next.
Results are typically available within 3–7 working days from when your sample reaches the laboratory, excluding weekends and bank holidays.
Urine Microscopy / Sediment
- Urine Casts
- Urine Crystals
- Organisms
Urine Blood & Cells
- Urine Blood
- Urine RBCs
- Urine WBC
- Urine Epithelial Cells
Urine Chemistry
- Urine Protein
- Urine Glucose
- Ketones
- Urine Bilirubin
- Urine Urobilinogen
- Urine pH
Inflammation
- C-reactive Protein, CRP
Liver Function
- Alanine Transferase
- Aspartate Transferase
- Alkaline Phosphatase
- Gamma GT
- Bilirubin
- Albumin
- Globulin
- Total Protein
Kidney Function
- Creatinine
- Estimated GFR
- Urea
How to prepare
- Fasting required 8–12 h before the test (water only) recommended for glucose, cholesterol/triglyceride accuracy
- Sample timing: between 7:00 AM – 10:00 AM
- Stay hydrated; avoid strenuous exercise, heavy meals, and supplements (iron, B12, multivitamins, biotin) for 48 hours prior
- Continue prescribed medications unless otherwise directed
Frequently asked questions
Who is this test for?
It is for adults experiencing puffiness or swelling, most often in the ankles, feet or lower legs. It examines the systems that regulate fluid balance in the body, including kidney function, liver function, protein levels and electrolytes.
Do I need to fast before this test?
Fasting is not usually required for this panel. Please stay normally hydrated and drink water as usual, as dehydration can alter kidney and electrolyte readings.
Should I see a doctor urgently instead of testing?
Yes, if the swelling came on suddenly, affects only one leg, or is accompanied by chest pain, breathlessness, or a hot and painful calf. Those symptoms need same-day medical assessment rather than a routine blood test. Please contact NHS 111, your GP, or attend A&E.
Can swelling happen even if my results are normal?
It can. Prolonged standing or sitting, heat, pregnancy, some medications and venous circulation problems can all cause swelling without altering blood chemistry. Normal results help rule out kidney, liver and protein-related causes so that other explanations can be examined.
Will this test check my heart?
This panel focuses on kidney function, liver function and fluid-regulating markers. If a cardiac cause is suspected, our Heart Health Blood Test is a better fit and your report will say so if the findings point that way.